Table 4. Multivariable analysis for HPV and occurrence of oral-pharyngeal-laryngeal cancer (n=115)
Variable |
Subgroup |
Odds Ratios(OR) |
95% confidence interval |
P-value |
HPV test result |
Both antibody & DNA -ve |
1 |
- |
- |
|
Antibody +ve & DNA -ve |
0.824 |
0.311-2.182 |
0.697 |
|
Antibody -ve & DNA +ve |
0.756 |
0.205-2.794 |
0.675 |
|
Both antibody & DNA + ve |
0.277 |
0.018-4.185 |
0.354 |
|
|
|
|
|
Gender |
Male |
1 |
- |
- |
|
Female |
1.01 |
0.376-3.225 |
0.86 |
|
|
|
|
|
Age-group |
18-49 |
1 |
- |
- |
|
50-69 |
2.553 |
0.858-7.597 |
0.092 |
|
70 or above |
1.632 |
0.474-5.617 |
0.437 |
|
|
|
|
|
Education level |
Primary or below |
1 |
- |
- |
|
Secondary |
0.611 |
0.23-1.622 |
0.322 |
|
Tertiary or above |
4.335 |
0.915-20.537 |
0.065 |
|
|
|
|
|
Smoking status |
Non-smoker |
1 |
- |
- |
|
Ever-smoker |
2.059 |
0.709-5.977 |
0.184 |
|
|
|
|
|
Alcohol usage |
No |
1 |
- |
- |
|
Yes |
1.827 |
0.609-5.486 |
0.282 |
|
|
|
|
|
*p<0.05 |
|
|
|
|
Table 5. Mortality rate and recurrence rate in HPV groups
|
Esophageal |
Oral-pharyngeal-laryngeal |
Overall |
|||
Cancer in subjects in group |
Mortality |
Recurrence |
Mortality |
Recurrence |
Mortality |
Recurrence |
Both antibody & DNA –ve |
75%(12/16) |
0(0/0/15) |
36.7%(11/30) |
23.1%(6/26) |
50%(23/46) |
14.6%(6/41) |
Antibody +ve & DNA –ve |
80% (4/5) |
0(0/13) |
33.3%(5/15) |
25%(3/12) |
45%(9/20) |
20%(3/15) |
Antibody –ve & DNA +ve |
NA |
NA |
83.3%(5/6) |
0(0/5) |
83.3%(5/6) |
0(0/5) |
Both antibody & DNA +ve |
NA |
NA |
0(0/1) |
0(0/1) |
0(0/1) |
0(0/1) |
Table 6. Cumulative probability of survival 2 years after diagnosis
HPV Group- Ever Smoker |
Diagnosis |
|
Esophageal (n=16) |
Oral-pharyngeal-laryngeal |
|
Both antibody & DNA -ve |
0.333 |
(n=14)0.714 |
Antibody +ve & DNA -ve |
0.250 |
(n=5)0.600 |
Antibody -ve & DNA +ve |
NA |
(n=4)0.250 |
Both antibody & DNA + ve |
NA |
NA |
p-value of Log rank test |
0.533 |
0.019 |
HPV Group-Non Smoker |
Diagnosis |
|
Esophageal (n=5) |
Oral-pharyngeal-laryngeal |
|
Both antibody & DNA -ve |
0 |
0.844 |
Antibody +ve & DNA -ve |
0 |
0.617 |
Antibody -ve & DNA +ve |
NA |
0.500 |
Both antibody & DNA +ve |
NA |
NA |
p-value of Log rank test |
0.754 |
0.708 |