Table 4. Multivariable analysis for HPV and occurrence of oral-pharyngeal-laryngeal cancer (n=115)

Variable

Subgroup

Odds Ratios(OR)

95% confidence interval

P-value

HPV test result

Both antibody & DNA -ve

1

-

 -

 

Antibody +ve & DNA -ve

0.824

0.311-2.182

0.697

 

Antibody -ve & DNA +ve

0.756

0.205-2.794

0.675

 

Both antibody & DNA + ve

0.277

0.018-4.185

0.354

 

 

 

 

 

Gender

Male

1

 -

 -

 

Female

1.01

0.376-3.225

0.86

 

 

 

 

 

Age-group

18-49

1

-

-

 

50-69

2.553

0.858-7.597

0.092

 

70 or above

1.632

0.474-5.617

0.437

 

 

 

 

 

Education level

Primary or below

1

-

-

 

Secondary

0.611

0.23-1.622

0.322

 

Tertiary or above

4.335

0.915-20.537

0.065

 

 

 

 

 

Smoking status

Non-smoker

1

 -

 -

 

Ever-smoker

2.059

0.709-5.977

0.184

 

 

 

 

 

Alcohol usage

No

 1

 -

 

 -

 

Yes

1.827

0.609-5.486

0.282

 

 

 

 

 

*p<0.05

 

 

 

 


Table 5. Mortality rate and recurrence rate in HPV groups

 

Esophageal

Oral-pharyngeal-laryngeal

Overall

Cancer in subjects in group

Mortality

Recurrence

Mortality

Recurrence

Mortality

Recurrence

Both antibody & DNA –ve

75%(12/16)

0(0/0/15)

36.7%(11/30)

23.1%(6/26)

50%(23/46)

14.6%(6/41)

Antibody +ve & DNA –ve

80% (4/5)

0(0/13)

33.3%(5/15)

25%(3/12)

45%(9/20)

20%(3/15)

Antibody –ve & DNA +ve

NA

NA

83.3%(5/6)

0(0/5)

83.3%(5/6)

0(0/5)

Both antibody & DNA +ve

NA

NA

0(0/1)

0(0/1)

0(0/1)

0(0/1)


Table 6. Cumulative probability of survival 2 years after diagnosis

HPV Group- Ever Smoker

Diagnosis

Esophageal (n=16)

Oral-pharyngeal-laryngeal
(n=23)

Both antibody & DNA -ve

0.333

(n=14)0.714

Antibody +ve & DNA -ve

0.250

(n=5)0.600

Antibody -ve & DNA +ve

NA

(n=4)0.250

Both antibody & DNA + ve

NA

NA

p-value of Log rank test

0.533

0.019

HPV Group-Non Smoker

Diagnosis

Esophageal (n=5)

Oral-pharyngeal-laryngeal
(n=16)

Both antibody & DNA -ve

0

0.844

Antibody +ve & DNA -ve

0

0.617

Antibody -ve & DNA +ve

NA

0.500

Both antibody & DNA +ve

NA

NA

p-value of Log rank test

0.754

0.708